Wednesday, November 29

08:00-20:00

Exhibit Setup

13:00-17:00

Arrivals and Registration

17:30-19:30

Evening Symposium A: Emerging Treatments for Diabetic Neuropathy
Supported by Ono Pharmaceutical Co., Ltd

Program Chairpersons :
Nigishi Hotta, MD, PhD ( Japan ), Co-chair
Anders AF Sima, MD, PhD ( USA ), Co-chair

Introduction
Anders AF Sima, MD, PhD (USA)

17:30-18:00

Onset of Diabetic Neuropathy and Its Natural History
Rayaz Malik, BSc, ChB, MRCP, PhD ( UK )

18:00-18:30

Polyol Pathway and Etiology of Diabetic Neuropathy
Soroku Yagihashi, MD, PhD ( Japan )

18:30-19:00

Global Standard of Assessment and Diagnosis of Diabetic Neuropathy
Vera Bril, BSc, MD, FRCPC ( Canada )

19:00-19:30

Worldwide View and Expected Effects of Treatments for Diabetic Neuropathy
Douglas Zochodne, MD, FRCPC ( Canada )

Closing Remarks
Nigishi Hotta, MD, PhD ( Japan )

19:30-21:00

Welcome Reception

Thursday, November 30

08:20-08:30

Opening Remarks
Aaron Vinik, MD, PhD, FCP, MACP ( USA )

 08:30-10:30

Session 1: Theories of Pathogenesis of Diabetic Neuropathy
Chairpersons:
Mary Cotter, PhD (UK)
Nigel Calcutt, PhD (USA)

08:30-09:00

CME Plenary: Cutting-Edge Theories of Pathogenesis of Diabetic Neuropathy
Eva Feldman, MD, PhD (USA)

09:00-10:30

Oral Abstract Presentations Session 1: Emerging Factors to the Pathogenesis of Diabetic Neuropathy

10:30-11:00

 Coffee Break

11:00-13:00

Session 2: Genomic Factors that Predispose to the Development of Diabetic Neuropathy
Chairpersons:
Doug Zochodne, MD, FRCPC (Canada)
David Fink, MD (USA)

11:00-11:30

CME Plenary: Genomic Factors that Predispose to the Development of Diabetic Neuropathy
David Tomlinson, BSc, PhD ( UK )

11:30-13:00

Oral Abstract Presentations Session 2: Genes and Molecules That Affect Diabetic Neuropathy

13:00-14:00

Lunch

14:00-15:30

Poster Session 1
Chairpersons:
Hitoshi Nukada, MD (New Zealand)
Peter Oates, PhD (USA)

15:30-16:30

Invited Lectures
Chairpersons:
Vera Bril, BSc, MD, FRCPC (Canada)
Hitoshi Yasuda, PhD (Japan)

15:30-16:00

Traditional Mechanisms of Neuropathic Pain in Animal Models
Nigel Calcutt, PhD ( USA )

16:00-16:30

Novel Mechanisms of Neuropathic Pain
Kazuhide Inoue, PhD ( Japan )

16:30-17:00

Coffee Break

17:00-19:00

Evening Symposium B: Pain: The Final Frontier – Emerging Opinions in Painful DPN
Supported by Pfizer Inc

Program Chairperson:
Roy Freeman, MD ( USA )

17:00-17:30

Epidemiology and Pathogenesis of Diabetic Peripheral Neuropathy
Solomon Tesfaye, MB, ChB, MD, FRCP ( UK )

17:30-18:00

A Multidimensional Approach to Quantifying Neuropathic Pain
Rainer Freynhagen , MD ( Germany )

18:00-18:30

Mechanisms of Neuropathic Pain – Therapeutic Targets
Roy Freeman, MD ( USA )

18:30-19:00

Translating Research to Practice - Clinical Management of Painful DPN
Andrew JM Boulton, MD, FRCP ( UK )

Friday, December 1

08:30-10:30

Session 3: Clinical Manifestations of Large- and Small-fiber Neuropathy
Chairpersons:
Andrew Boulton, MD, FRCP (UK)
Solomon Tesfaye, MB, ChB, MD, FRCP (UK)

08:30-09:00

CME Plenary: Clinical Manifestations of Large- and Small-fiber Neuropathy
Aaron Vinik, MD, PhD, FCP, MACP ( USA )

Supported by an educational grant from Eli Lilly and Company and Boehringer Ingelheim

09:00-10:30

Oral Abstract Presentations Session 3: Large- and Small-fiber Neuropathies

10:30-11:00

Coffee Break

11:00-13:30

Session 4: Cardiovascular, Gastrointestinal, and Genitourinary Dysfunctions Induced by Autonomic Neuropathy

11:00-11:30

CME Plenary: Cardiovascular and Gastrointestinal Dysfunctions Induced by Autonomic Neuropathy
Dan Ziegler, MD, FRCP (Germany)
Supported by an educational grant from ANSAR Medical Technologies, Inc.

11:30-12:00

CME Plenary: Erectile Dysfunction Induced by Autonomic Neuropathy
Peter Kempler, MD, PhD, DSc ( Hungary )
Chairpersons:
Nigishi Hotta, MD, PhD (Japan)
Dan Ziegler, MD, FRCP (Germany)

12:00-13:30

Oral Abstract Presentations Session 4: Cardiovascular, Gastrointestinal, and Genitourinary Dysfunctions Induced by Autonomic Neuropathy

13:30-14:30

Lunch

14:30-16:00

Poster Session 2
Chairpersons:
Hitoshi Nukada, MD (New Zealand)
Peter Oates, PhD (USA)
(Refreshments will be served)

16:00-18:00

Evening CME Symposium C: Recent Developments in Prediabetic Neuropathies
Supported by an educational grant from Eli Lilly and Company and Boehringer Ingelheim
Program Chairpersons:
Eva Feldman, MD, PhD (USA)
William Kennedy, MD (USA)

16:00-16:30

The Emergence of Prediabetic Neuropathies
William Kennedy, MD (USA)

16:30-17:00

Mechanisms of Prediabetic Neuropathies
Irina Obrosova, PhD (USA)

17:00-17:30

New Devices for Quantification of Large- vs Small-fiber Neuropathies
Dan Ziegler, MD, FRCP (Germany)

17:30-18:00

Models and Consequences of Pre-diabetic Autonomic and Somatosensory Neuropathy
Roy Freeman, MD (USA)

18:00-20:00

Chairman's Dinner and CME Lecture: The Potential for Gene Therapy to Prevent and Reverse Diabetic Peripheral Neuropathy

David Fink, MD ( USA )
Supported by an educational grant from Takeda Pharmaceuticals North America, Inc.

Chairpersons:
Aaron Vinik, MD, PhD, FCP, MACP (USA)
Soroku Yagihasi, MD, PhD (Japan)

Saturday, December 2

08:00-14:00

Dismantle Exhibits

08:30-10:30

Session 5: Management of the Diabetic Foot
Chairpersons:
David Armstrong, DPM, PhD (USA)
Andrew Boulton, MD, FRCP (UK)

08:30-09:00

CME Plenary: An Overview of the Diabetic Foot
Andrew Boulton, MD, FRCP ( UK )

09:00-09:30

CME Plenary: Management of Foot Ulcers and Foot Infections
David Armstrong, DPM, PhD ( USA )

09:30-10:30

Oral Abstract Presentations Session 5: Behavioral and Predictive Factors of Neuropathy and Its Complications

10:30-11:00

Coffee Break

11:00-12:30

Expert Debate: Of Mice and Men: Benefits and Limitations of Animal Models and Clinical Trials

Moderators:
Aaron Vinik, MD, PhD, FCP, MACP ( USA )
Soroku Yagihashi, MD, PhD ( Japan )

11:00-11:30

Why Drugs Have Great Results in Animal Experiments Yet Fail in Clinical Trials
Mary Cotter, PhD ( UK )

11:30-12:00

Why Clinical Trials Are Well Designed Yet the Drugs Don't Get Great Results
Douglas Zochodne, MD, FRCPC ( Canada )

12:00-12:30

Discussion

12:30-12:45

Concluding Remarks
Aaron Vinik, MD, PhD, FCP, MACP ( USA )